Pesquisa | Secretaria de Estado da Saúde

1.

The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist.

Collora, Jack A; Ho, Ya-Chi.

Cell ; 185(2): 227-229, 2022 01 20.

Artigo Inglês | MEDLINE | ID: mdl-35063069

2.

Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.

Wei, Yulong; Davenport, Timothy C; Collora, Jack A; Ma, Haocong Katherine; Pinto-Santini, Delia; Lama, Javier; Alfaro, Ricardo; Duerr, Ann; Ho, Ya-Chi.

Immunity ; 56(11): 2584-2601.e7, 2023 Nov 14.

Artigo Inglês | MEDLINE | ID: mdl-37922905

3.

Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.

Collora, Jack A; Liu, Runxia; Pinto-Santini, Delia; Ravindra, Neal; Ganoza, Carmela; Lama, Javier R; Alfaro, Ricardo; Chiarella, Jennifer; Spudich, Serena; Mounzer, Karam; Tebas, Pablo; Montaner, Luis J; van Dijk, David; Duerr, Ann; Ho, Ya-Chi.

Immunity ; 55(6): 1013-1031.e7, 2022 06 14.

Artigo Inglês | MEDLINE | ID: mdl-35320704

4.

Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates.

Wei, Yulong; Ho, Ya-Chi.

Mol Cell ; 82(24): 4585-4587, 2022 12 15.

Artigo Inglês | MEDLINE | ID: mdl-36525953

5.

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Ho, Ya-Chi; Shan, Liang; Hosmane, Nina N; Wang, Jeffrey; Laskey, Sarah B; Rosenbloom, Daniel I S; Lai, Jun; Blankson, Joel N; Siliciano, Janet D; Siliciano, Robert F.

Cell ; 155(3): 540-51, 2013 Oct 24.

Artigo Inglês | MEDLINE | ID: mdl-24243014

6.

Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation.

Collora, Jack A; Ho, Ya-Chi.

Genome Res ; 33(6): 891-906, 2023 06.

Artigo Inglês | MEDLINE | ID: mdl-37295842

7.

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.

Bruner, Katherine M; Wang, Zheng; Simonetti, Francesco R; Bender, Alexandra M; Kwon, Kyungyoon J; Sengupta, Srona; Fray, Emily J; Beg, Subul A; Antar, Annukka A R; Jenike, Katharine M; Bertagnolli, Lynn N; Capoferri, Adam A; Kufera, Joshua T; Timmons, Andrew; Nobles, Christopher; Gregg, John; Wada, Nikolas; Ho, Ya-Chi; Zhang, Hao; Margolick, Joseph B; Blankson, Joel N; Deeks, Steven G; Bushman, Frederic D; Siliciano, Janet D; Laird, Gregory M; Siliciano, Robert F.

Nature ; 566(7742): 120-125, 2019 02.

Artigo Inglês | MEDLINE | ID: mdl-30700913

8.

TCR-mimic bispecific antibodies to target the HIV-1 reservoir.

Sengupta, Srona; Board, Nathan L; Wu, Fengting; Moskovljevic, Milica; Douglass, Jacqueline; Zhang, Josephine; Reinhold, Bruce R; Duke-Cohan, Jonathan; Yu, Jeanna; Reed, Madison C; Tabdili, Yasmine; Azurmendi, Aitana; Fray, Emily J; Zhang, Hao; Hsiue, Emily Han-Chung; Jenike, Katharine; Ho, Ya-Chi; Gabelli, Sandra B; Kinzler, Kenneth W; Vogelstein, Bert; Zhou, Shibin; Siliciano, Janet D; Sadegh-Nasseri, Scheherazade; Reinherz, Ellis L; Siliciano, Robert F.

Proc Natl Acad Sci U S A ; 119(15): e2123406119, 2022 04 12.

Artigo Inglês | MEDLINE | ID: mdl-35394875

9.

Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting.

Sun, Yu; Abriola, Laura; Niederer, Rachel O; Pedersen, Savannah F; Alfajaro, Mia M; Silva Monteiro, Valter; Wilen, Craig B; Ho, Ya-Chi; Gilbert, Wendy V; Surovtseva, Yulia V; Lindenbach, Brett D; Guo, Junjie U.

Proc Natl Acad Sci U S A ; 118(26)2021 06 29.

Artigo Inglês | MEDLINE | ID: mdl-34185680

10.

Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen.

Pedersen, Savannah F; Collora, Jack A; Kim, Rachel N; Yang, Kerui; Razmi, Anya; Catalano, Allison A; Yeh, Yang-Hui Jimmy; Mounzer, Karam; Tebas, Pablo; Montaner, Luis J; Ho, Ya-Chi.

J Virol ; 96(13): e0057722, 2022 07 13.

Artigo Inglês | MEDLINE | ID: mdl-35730977

11.

The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency.

Mori, Luisa; Jenike, Katharine; Yeh, Yang-Hui Jimmy; Lacombe, Benoît; Li, Chuan; Getzler, Adam; Mediouni, Sonia; Cameron, Michael; Pipkin, Matthew; Ho, Ya-Chi; Ramirez, Bertha Cecilia; Valente, Susana.

J Virol ; 95(4)2021 02 15.

Artigo Inglês | MEDLINE | ID: mdl-33239456

12.

Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.

Taura, Manabu; Song, Eric; Ho, Ya-Chi; Iwasaki, Akiko.

Proc Natl Acad Sci U S A ; 116(6): 2282-2289, 2019 02 05.

Artigo Inglês | MEDLINE | ID: mdl-30670656

13.

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.

Wang, Zheng; Gurule, Evelyn E; Brennan, Timothy P; Gerold, Jeffrey M; Kwon, Kyungyoon J; Hosmane, Nina N; Kumar, Mithra R; Beg, Subul A; Capoferri, Adam A; Ray, Stuart C; Ho, Ya-Chi; Hill, Alison L; Siliciano, Janet D; Siliciano, Robert F.

Proc Natl Acad Sci U S A ; 115(11): E2575-E2584, 2018 03 13.

Artigo Inglês | MEDLINE | ID: mdl-29483265

14.

The forces driving clonal expansion of the HIV-1 latent reservoir.

Liu, Runxia; Simonetti, Francesco R; Ho, Ya-Chi.

Virol J ; 17(1): 4, 2020 01 07.

Artigo Inglês | MEDLINE | ID: mdl-31910871

15.

Shock-and-kill versus block-and-lock: Targeting the fluctuating and heterogeneous HIV-1 gene expression.

Yeh, Yang-Hui Jimmy; Ho, Ya-Chi.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Artigo Inglês | MEDLINE | ID: mdl-33758027

16.

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.

Yukl, Steven A; Boritz, Eli; Busch, Michael; Bentsen, Christopher; Chun, Tae-Wook; Douek, Daniel; Eisele, Evelyn; Haase, Ashley; Ho, Ya-Chi; Hütter, Gero; Justement, J Shawn; Keating, Sheila; Lee, Tzong-Hae; Li, Peilin; Murray, Danielle; Palmer, Sarah; Pilcher, Christopher; Pillai, Satish; Price, Richard W; Rothenberger, Meghan; Schacker, Timothy; Siliciano, Janet; Siliciano, Robert; Sinclair, Elizabeth; Strain, Matt; Wong, Joseph; Richman, Douglas; Deeks, Steven G.

PLoS Pathog ; 9(5): e1003347, 2013.

Artigo Inglês | MEDLINE | ID: mdl-23671416

17.

Investigation of the Anti-Melanogenic and Antioxidant Characteristics of Eucalyptus camaldulensis Flower Essential Oil and Determination of Its Chemical Composition.

Huang, Huey-Chun; Ho, Ya-Chi; Lim, Jia-Min; Chang, Tzu-Yun; Ho, Chen-Lung; Chang, Tsong-Min.

Int J Mol Sci ; 16(5): 10470-90, 2015 May 07.

Artigo Inglês | MEDLINE | ID: mdl-25961954

18.

Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels.

Wong, Michelle; Wei, Yulong; Ho, Ya-Chi.

Curr Opin HIV AIDS ; 18(5): 246-256, 2023 09 01.

Artigo Inglês | MEDLINE | ID: mdl-37535039

19.

Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.

Hollander, Klarissa; Chan, Albert H; Frey, Kathleen M; Hunker, Olivia; Ippolito, Joseph A; Spasov, Krasimir A; Yeh, Yang-Hui J; Jorgensen, William L; Ho, Ya-Chi; Anderson, Karen S.

Protein Sci ; 32(12): e4814, 2023 Dec.

Artigo Inglês | MEDLINE | ID: mdl-37861472

20.

Measuring reversal of HIV-1 latency ex vivo using cells from infected individuals.

Ho, Ya-Chi; Laird, Gregory M; Siliciano, Robert F.

Proc Natl Acad Sci U S A ; 111(19): 6860-1, 2014 May 13.

Artigo Inglês | MEDLINE | ID: mdl-24799684

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